1.1: oxalyl dichloride / 2 h / Reflux 2.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C 3.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C 4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 4.2: 0.67 h / -78 - -60 °C / Inert atmosphere 5.1: hydrogenchloride; water / methanol / 2 h / 20 °C 6.1: potassium hydroxide / ethanol; water / 12 h / Reflux 7.1: pyridine / 20 °C 8.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 9.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 10.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1.1: oxalyl dichloride / 2 h / Reflux 2.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C 3.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C 4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 4.2: 0.67 h / -78 - -60 °C / Inert atmosphere 5.1: hydrogenchloride; water / methanol / 2 h / 20 °C 6.1: potassium hydroxide / ethanol; water / 12 h / Reflux 7.1: pyridine / 20 °C 8.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 9.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 10.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C / Inert atmosphere1.2: -78 - 20 °C / Inert atmosphere2.1: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 20 °C / 760.05 Torr3.1: water / ethanol / 4 h / Reflux  

Multi-step reaction with 2 steps 1: oxalyl dichloride / 2 h / Reflux2: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C