1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 0.67 h / -78 - -60 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: potassium hydroxide / ethanol; water / 12 h / Reflux 4.1: pyridine / 20 °C 5.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 7.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 0.67 h / -78 - -60 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: potassium hydroxide / ethanol; water / 12 h / Reflux 4.1: pyridine / 20 °C 5.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 7.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '124246', constants.ctx, '0')">2,4,6-trichloro-1,3,5-triazine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=20&deg;C;&nbsp;16&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 &deg;C / Inert atmosphere<br />1.2: -78 - 20 &deg;C / Inert atmosphere<br />2.1: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 20 &deg;C / 760.05 Torr<br />3.1: water / ethanol / 4 h / Reflux<br />4.1: oxalyl dichloride / 2 h / Reflux<br />5.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 &deg;C<br />6.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: oxalyl dichloride / 2 h / Reflux<br />2: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 &deg;C<br />3: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 &deg;C<br /> <br /> &nbsp;