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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1260522-94-8
合成路线
（共 5 条）
1260522-94-8
→
反应条件
16562-14-4
3,9-二甲氧基-5,8,13,13alpha-四氢-6H-异喹啉并[3,2-a]异喹啉-2,10-二醇
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 2: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Cheng, Jianjun; Fu, Liqiang; Ling, Chenyu; Yang, Yushe
Heterocycles, 2010 , vol. 81, # 11 p. 2581 - 2592
1260522-94-8
→
反应条件
16562-14-4
3,9-二甲氧基-5,8,13,13alpha-四氢-6H-异喹啉并[3,2-a]异喹啉-2,10-二醇
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 2: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Cheng, Jianjun; Fu, Liqiang; Ling, Chenyu; Yang, Yushe
Heterocycles, 2010 , vol. 81, # 11 p. 2581 - 2592
1258935-43-1
→
反应条件
1260522-94-8
反应条件
<b>Multi-step reaction with 11 steps<br /> </b>1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C / Inert atmosphere<br />1.2: -78 - 20 °C / Inert atmosphere<br />2.1: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 20 °C / 760.05 Torr<br />3.1: water / ethanol / 4 h / Reflux<br />4.1: oxalyl dichloride / 2 h / Reflux<br />5.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C<br />6.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C<br />7.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere<br />7.2: 0.67 h / -78 - -60 °C / Inert atmosphere<br />8.1: hydrogenchloride; water / methanol / 2 h / 20 °C<br />9.1: potassium hydroxide / ethanol; water / 12 h / Reflux<br />10.1: pyridine / 20 °C<br />11.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C<br /> <br />
参考文献
Cheng, Jianjun; Fu, Liqiang; Ling, Chenyu; Yang, Yushe Heterocycles, 2010 , vol. 81, # 11 p. 2581 - 2592
1260522-88-0
→
反应条件
1260522-94-8
反应条件
<b>Multi-step reaction with 8 steps<br /> </b>1.1: oxalyl dichloride / 2 h / Reflux<br />2.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C<br />3.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C<br />4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere<br />4.2: 0.67 h / -78 - -60 °C / Inert atmosphere<br />5.1: hydrogenchloride; water / methanol / 2 h / 20 °C<br />6.1: potassium hydroxide / ethanol; water / 12 h / Reflux<br />7.1: pyridine / 20 °C<br />8.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C<br /> <br />
参考文献
Cheng, Jianjun; Fu, Liqiang; Ling, Chenyu; Yang, Yushe Heterocycles, 2010 , vol. 81, # 11 p. 2581 - 2592
1260522-89-1
→
反应条件
1260522-94-8
反应条件
<b>Multi-step reaction with 6 steps<br /> </b>1.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C<br />2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere<br />2.2: 0.67 h / -78 - -60 °C / Inert atmosphere<br />3.1: hydrogenchloride; water / methanol / 2 h / 20 °C<br />4.1: potassium hydroxide / ethanol; water / 12 h / Reflux<br />5.1: pyridine / 20 °C<br />6.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C<br /> <br />
参考文献
Cheng, Jianjun; Fu, Liqiang; Ling, Chenyu; Yang, Yushe Heterocycles, 2010 , vol. 81, # 11 p. 2581 - 2592
