反应条件
1: 94.7 percent / HOBT, 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide (WSCD) / dimethylformamide / 3.5 h / 0 - 20 °C
2: 100 percent / HCl / CH2Cl2; dioxane / 1.17 h / 0 - 20 °C
3: 82.4 percent / Et3N / CH2Cl2 / 0.33 h / -15 °C
View Scheme
参考文献
Hagiwara, Daijiro; Miyake, Hiroshi; Morimoto, Hiroshi; Murai, Masako; Fujii, Takashi; Matsuo, Masaaki
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3184 - 3191
