反应条件
1: triethylamine / dichloromethane / 1.42 h / 2 - 22 °C / Inert atmosphere 2: sodium t-butanolate / tetrahydrofuran / 1 h / 19 - 65 °C / Inert atmosphere 3: hydrogen / 5 Pd(II)/C(eggshell) / ethanol / 3 h / 60 °C / 749.88 Torr 4: hydrogenchloride; water / 4 h / Reflux 5: thionyl chloride / dichloromethane View Scheme
参考文献
ABBOTT LABORATORIES; CHEMBURKAR, Sanjay, R.; REDDY, Rajarathman, E.; REAMER, Douglas, M.; PAVLINA, John, T.; ULREY, Stephen, S.; KOTECKI, Brian, J.
Patent: WO2011/9021 A1, 2011 ;
