4-[[(1,1-二甲基乙氧基)羰基]氨基]-1-甲基-1H-吡咯-2-羧酸甲酯合成路线 （共 18 条）
反应条件
potassium phosphate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in 1,4-dioxane T=110°C; 48 h;
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
sodium carbonate in 1,4-dioxane 3 h;
参考文献
Journal of the American Chemical Society, , vol. 118, # 26 p. 6141 - 6146
反应条件
1: 91 percent / CH2Cl2 / 24 h 2: 81 percent / N-bromosuccinimide / CH2Cl2 / 18 h / -10 - 20 °C 3: 93 percent / methanol / 1 h 4: 99 percent / K3PO4; N,N'-dimethylethylenediamine / CuI / dioxane / 48 h / 110 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 81 percent / N-bromosuccinimide / CH2Cl2 / 18 h / -10 - 20 °C 2: 93 percent / methanol / 1 h 3: 99 percent / K3PO4; N,N'-dimethylethylenediamine / CuI / dioxane / 48 h / 110 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 93 percent / methanol / 1 h 2: 99 percent / K3PO4; N,N'-dimethylethylenediamine / CuI / dioxane / 48 h / 110 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
in dichloromethane 12 h; Heating;
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 11 p. 910 - 917
反应条件
1: 90 percent / sodium carbonate / acetone / 18 h / Heating 2: 35 percent / nitric acid, acetic anhydride / 1) -20 deg C, 6 h; 2) room temperature, 4 h 3: H2 / Ni-raney / ethanol / 12 h / 50 °C 4: 84 percent / CH2Cl2 / 12 h / Heating View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 11 p. 910 - 917
反应条件
1: 35 percent / nitric acid, acetic anhydride / 1) -20 deg C, 6 h; 2) room temperature, 4 h 2: H2 / Ni-raney / ethanol / 12 h / 50 °C 3: 84 percent / CH2Cl2 / 12 h / Heating View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 11 p. 910 - 917
反应条件
1: H2 / Ni-raney / ethanol / 12 h / 50 °C 2: 84 percent / CH2Cl2 / 12 h / Heating View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 11 p. 910 - 917
