4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C;

4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 18 h;

N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=23°C; 18 h;

1: N-Methyl-4-nitropyrrole-2-carboxylic Acid Methyl Ester With hydrogen; palladium 10 on activated carbon in ethyl acetate T=20°C; 12 h; 2: 4-[[(tert-Butyloxy)carbonyl]-amino]-1-methylpyrrole-2-carboxylic acid With 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 3 h;

1: 90 percent / sodium carbonate / acetone / 18 h / Heating 2: 35 percent / nitric acid, acetic anhydride / 1) -20 deg C, 6 h; 2) room temperature, 4 h 3: H2 / Ni-raney / ethanol / 12 h / 50 °C 4: 84 percent / CH2Cl2 / 12 h / Heating 5: 93 percent / aq. NaOH / methanol / 18 h / Heating 6: dicyclohexylcarbodiimide, dimethylaminopyridine / CH2Cl2 / 4 h View Scheme

1: 35 percent / nitric acid, acetic anhydride / 1) -20 deg C, 6 h; 2) room temperature, 4 h 2: H2 / Ni-raney / ethanol / 12 h / 50 °C 3: 84 percent / CH2Cl2 / 12 h / Heating 4: 93 percent / aq. NaOH / methanol / 18 h / Heating 5: dicyclohexylcarbodiimide, dimethylaminopyridine / CH2Cl2 / 4 h View Scheme

1: H2 / Ni-raney / ethanol / 12 h / 50 °C 2: 84 percent / CH2Cl2 / 12 h / Heating 3: 93 percent / aq. NaOH / methanol / 18 h / Heating 4: dicyclohexylcarbodiimide, dimethylaminopyridine / CH2Cl2 / 4 h View Scheme

1: trifluoroacetic acid / CH2Cl2; H2O / 0.5 h 2: 0.15 g / 3-(diethoxy-phosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; triethylamine / CH2Cl2 / 17 h View Scheme

1: 84 percent / CH2Cl2 / 12 h / Heating 2: 93 percent / aq. NaOH / methanol / 18 h / Heating 3: dicyclohexylcarbodiimide, dimethylaminopyridine / CH2Cl2 / 4 h View Scheme

1: 84 percent / CH2Cl2 / 12 h / Heating 2: 93 percent / aq. NaOH / methanol / 18 h / Heating 3: dicyclohexylcarbodiimide, dimethylaminopyridine / CH2Cl2 / 4 h View Scheme