2,2-二氟-苯并[1,3]二氧代-4-硼酸合成路线 (共 4 条)
反应条件
1: 4-bromo-2,2-difluoro-1,3-benzodioxole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: boric acid trimethyl ester in tetrahydrofuran; hexane T=-78 - 20°C; 2 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=0 - 20°C; 0.333333 h;
参考文献
WO2008/148853 A1, ;
Page/Page column 86 ;
WO 2008/148853 A1
反应条件
1: 2,2-difluoro-1,3-benzodioxole With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 1.5 h; 2: boric acid trimethyl ester in tetrahydrofuran; cyclohexane T=-78 - -30°C; 3: With hydrogenchloride; water in tetrahydrofuran; cyclohexane
参考文献
WO2012/76877 A1, ;
Page/Page column 167-168 ;
WO 2012/076877 A1
反应条件
1: With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 1.5 h; 2: With boric acid trimethyl ester in tetrahydrofuran; cyclohexane T=-78 - -30°C; 3: With hydrogenchloride; water in tetrahydrofuran; cyclohexane
参考文献
US2013/267510 A1, ;
Paragraph 1074-1076 ;
反应条件
hydrogenchloride; n-butyllithium; sodium chloride in tetrahydrofuran; Petroleum ether