1: 2-chloro-4-(difluoromethyl)pyrimidine; 3-bromo-aniline With methanesulfonic acid in 1,4-dioxane; dichloromethane T=95°C; 10 h; 2: acetic anhydride With 4-(N,N-dimethlyamino)pyridine in dichloromethane 0.5 h;