(+-)-4-氨基-4,11-二乙基-9-羟基-1H-吡喃并(3',4':6,7)吲哚嗪并(1,2-b)喹啉-3,14(4H,12H)-二酮合成路线 （共 9 条）
反应条件
1: 2.) p-TsOH*H2O / 1.) toluene, reflux, 0.5 h, 2.) toluene, reflux, 3 h 2: 46.9 percent / H2 / PtO2*H2O / ethanol; dioxane / 6 h / Irradiation 3: 47percent aq.HBr / 3 h / Heating View Scheme
参考文献
Ejima; Terasawa; Sugimori; Ohsuki; Matsumoto; Kawato; Yasuoka; Tagawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 683 - 688
反应条件
1: 38.9 percent / pyridine / 2 h / 0 °C 2: 100 percent / NaN3 / dimethylformamide / 3 h / 60 °C 3: 52.7 percent / H2 / 10percent Pd/C / ethanol; dioxane / 3 h 4: 100 percent / H2O / 1 h / Ambient temperature 5: 47 percent / p-TsOH*H2O / toluene / 4 h / Heating 6: 47percent aq.HBr / 3 h / Heating View Scheme
参考文献
Ejima; Terasawa; Sugimori; Ohsuki; Matsumoto; Kawato; Yasuoka; Tagawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 683 - 688
反应条件
1: 52.7 percent / H2 / 10percent Pd/C / ethanol; dioxane / 3 h 2: 100 percent / H2O / 1 h / Ambient temperature 3: 47 percent / p-TsOH*H2O / toluene / 4 h / Heating 4: 47percent aq.HBr / 3 h / Heating View Scheme
参考文献
Ejima; Terasawa; Sugimori; Ohsuki; Matsumoto; Kawato; Yasuoka; Tagawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 683 - 688
反应条件
1: 100 percent / NaN3 / dimethylformamide / 3 h / 60 °C 2: 52.7 percent / H2 / 10percent Pd/C / ethanol; dioxane / 3 h 3: 100 percent / H2O / 1 h / Ambient temperature 4: 47 percent / p-TsOH*H2O / toluene / 4 h / Heating 5: 47percent aq.HBr / 3 h / Heating View Scheme
参考文献
Ejima; Terasawa; Sugimori; Ohsuki; Matsumoto; Kawato; Yasuoka; Tagawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 683 - 688
反应条件
1: 2.) p-TsOH*H2O / 1.) toluene, reflux, 0.5 h, 2.) toluene, reflux, 3 h 2: 46.9 percent / H2 / PtO2*H2O / ethanol; dioxane / 6 h / Irradiation 3: 47percent aq.HBr / 3 h / Heating View Scheme
参考文献
Ejima; Terasawa; Sugimori; Ohsuki; Matsumoto; Kawato; Yasuoka; Tagawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 683 - 688
反应条件
1: 46.9 percent / H2 / PtO2*H2O / ethanol; dioxane / 6 h / Irradiation 2: 47percent aq.HBr / 3 h / Heating View Scheme
参考文献
Ejima; Terasawa; Sugimori; Ohsuki; Matsumoto; Kawato; Yasuoka; Tagawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 683 - 688
反应条件
1: 100 percent / H2O / 1 h / Ambient temperature 2: 47 percent / p-TsOH*H2O / toluene / 4 h / Heating 3: 47percent aq.HBr / 3 h / Heating View Scheme
参考文献
Ejima; Terasawa; Sugimori; Ohsuki; Matsumoto; Kawato; Yasuoka; Tagawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 683 - 688
反应条件
1: 47 percent / p-TsOH*H2O / toluene / 4 h / Heating 2: 47percent aq.HBr / 3 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 3 p. 683 - 688
反应条件
hydrogen bromide 3 h; Heating;
参考文献
Ejima; Terasawa; Sugimori; Ohsuki; Matsumoto; Kawato; Yasuoka; Tagawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 683 - 688
