2-溴-5-氨基-6-甲基吡啶合成路线 （共 5 条）
反应条件
hydrogen bromide; dihydrogen peroxide T=70°C; 1 h; Product distribution;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 331, # 3 p. 369 - 374
反应条件
zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0) in isobutyramide T=20°C; 22 h;
参考文献
Laboratoires Fournier S.A.
Patent: US2007/54955 A1, 2007 ;
Location in patent: Page/Page column 5 ;
反应条件
copper dichloride; isopentyl nitrite in acetonitrile T=20 - 65°C; 4 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/81569 A2, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
(CuOTf)2.C6H6; N-methyl-2-(methylamino)ethylamine in dimethyl sulfoxide
T=150°C; 4 h;
参考文献
Erickson, Shawn David; Gillespie, Paul; Guertin, Kevin Richard; Karnachi, Prabha Saba; Kim, Kyungjin; Ma, Chun; McComas, Warren William; Pietranico-Cole, Sherrie Lynn; Qi, Lida; Tilley, Jefferson Wright; Zhang, Qiang
Patent: US2009/286812 A1, 2009 ;
Location in patent: Page/Page column 19 ;
反应条件
methanesulfinic acid sodium salt; (CuOTf)2.C6H6; N-methyl-2-(methylamino)ethylamine in dimethyl sulfoxide
T=150°C; 4 h; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2008/5576 A1, 2008 ;
Location in patent: Page/Page column 28 ;
