2-(氯甲基)-4-苯基喹啉-3-甲酸乙酯合成路线 （共 3 条）
反应条件
Sc(DS)3 in water T=40°C; Friedlaender annulation;
参考文献
Zhang, Liang; Wu, Jie
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 7 p. 1047 - 1051
反应条件
1: 84 percent / 3N HCl / ethanol / 96 h / Heating
2: 1.) LAH / 2.) Pd/C / 1.) THF, RT, 30 min, 2.) EtOH, RT, overnight
3: 86 percent / MnO2 / CHCl3 / 1 h / Ambient temperature
4: ethanol / Heating
5: 97 percent / SOCl2 / CH2Cl2 / 5 h / Ambient temperature
6: 88 percent / NaH / dimethylformamide / 0.17 h / 0 °C
View Scheme
参考文献
Anzini, Maurizio; Capelli, Andrea; Vomero, Salvatore
Heterocycles, 1994 , vol. 38, # 1 p. 103 - 112
反应条件
hydrogenchloride in ethanol; water
216 h; RefluxInert atmosphere;
参考文献
Blair, Adele; Stevenson, Louise; Dewar, Deborah; Pimlott, Sally L.; Sutherland, Andrew
MedChemComm, 2013 , vol. 4, # 11 p. 1461 - 1466
