1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - 20°C; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=20°C;

1: 2,5-difluoropyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 4 h; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: With water; sodium hydroxide in tetrahydrofuran; hexane T=20°C;