1.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C / |Large scale 2.1: nitric acid / nitromethane / 8 h / 20 - 35 °C / |Large scale 3.1: hydrogen / methanol / 12 h / 20 °C / 760.05 Torr / |Large scale 4.1: acetic acid / 5 h / 20 °C / |Large scale 5.1: sodium t-butanolate / tert-butyl alcohol / 3 h / |Reflux; |Large scale 5.2: 1 h / 40 - 50 °C / pH Ca. 4 / |Large scale 6.1: trichlorophosphate; 4-(N,N-dimethlyamino)pyridine / ethyl acetate / 3 h / |Reflux; |Large scale View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C / |Large scale 2: nitric acid / nitromethane / 8 h / 20 - 35 °C / |Large scale View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C / |Large scale 2: nitric acid / nitromethane / 8 h / 20 - 35 °C / |Large scale 3: hydrogen / methanol / 12 h / 20 °C / 760.05 Torr / |Large scale View Scheme

potassium carbonate in N,N-dimethyl-formamide T=60°C; 6 h; Large scale reaction;