1: triethylamine / dichloromethane / 29 h 2: sodium hydrogencarbonate; Oxonereg; / water; acetone; ethyl acetate / 17 h 3: hexane / 1 h / 5 - 45 °C View Scheme

1: triethylamine / dichloromethane / 29 h 2: sodium hydrogencarbonate; Oxonereg; / water; acetone; ethyl acetate / 17 h 3: hexane / 1 h / 5 - 45 °C View Scheme

triethylamine in dichloromethane 29 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1724849', constants.ctx, '0')">N-Acetyl-Dl-leucine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />&nbsp;Resolution of racemate;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1724849', constants.ctx, '0')">N-Acetyl-Dl-leucine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098242', constants.ctx, '0')">propan-1-ol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />T=20 - 95&deg;C;&nbsp;&nbsp;Resolution of racemate;&nbsp;&nbsp;Reagent/catalystSolvent;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102719', constants.ctx, '0')">4-methyl-morpholine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '19273156', constants.ctx, '0')">imidazole modified Wang resin</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3704116', constants.ctx, '0')">sulfur trioxide pyridine complex</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '742035', constants.ctx, '0')">trifluoroacetic acid</a> <br />&nbsp;Multistep reaction;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 88 percent / NaBH₄; H₂SO₄ / diethyl ether / 0 &deg;C<br />2: 81 percent / Et₃N / CH₂Cl₂ / 20 &deg;C<br />3: 98 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 &deg;C<br />4: 72 percent / n-BuLi / tetrahydrofuran / -78 &deg;C<br />5: 32 percent HCl / acetone / Heating<br /> <br /> &nbsp;