(S)-氮丙啶-1,2-二羧酸 1-叔丁酯 2-甲酯合成路线 （共 13 条）
反应条件
1: (S)-1-trityl-aziridine-2-carboxylic acid methyl ester With trifluoroacetic acid in methanol; dichloromethane T=-30 - 0°C; Inert atmosphere; 2: di-tert-butyl dicarbonate With triethylamine in acetonitrile T=0 - 20°C; Inert atmosphere;
参考文献
Wu, Yan-Chao; Zhu, Jieping
Organic Letters, 2009 , vol. 11, # 23 p. 5558 - 5561
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine 12 h;
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
反应条件
indole; hafnium(IV) trifluoromethanesulfonate in dichloromethane T=20°C; 24 h;
参考文献
Tirotta, Ilaria; Fifer, Nathan L.; Eakins, Julia; Hutton, Craig A.
Tetrahedron Letters, 2013 , vol. 54, # 7 p. 618 - 620
反应条件
copper(II) bis(trifluoromethanesulfonate) in dichloromethane T=20°C; 24 h;
参考文献
Tirotta, Ilaria; Fifer, Nathan L.; Eakins, Julia; Hutton, Craig A.
Tetrahedron Letters, 2013 , vol. 54, # 7 p. 618 - 620
反应条件
scandium tris(trifluoromethanesulfonate) in dichloromethane T=20°C; 24 h;
参考文献
Tirotta, Ilaria; Fifer, Nathan L.; Eakins, Julia; Hutton, Craig A.
Tetrahedron Letters, 2013 , vol. 54, # 7 p. 618 - 620
反应条件
1: 96 percent / LiOH / H2O; dioxane 2: 19 percent / BF3*Et2O / acetone; cyclohexane / 12 h 3: 50 percent / CuBr*Me2S / tetrahydrofuran / 4 h / -40 °C 4: trifluoroacetic acid View Scheme
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
反应条件
copper(II) bis(trifluoromethanesulfonate) in dichloromethane T=20°C; 24 h;
参考文献
Tirotta, Ilaria; Fifer, Nathan L.; Eakins, Julia; Hutton, Craig A.
Tetrahedron Letters, 2013 , vol. 54, # 7 p. 618 - 620
反应条件
scandium tris(trifluoromethanesulfonate) in dichloromethane T=20°C; 24 h;
参考文献
Tirotta, Ilaria; Fifer, Nathan L.; Eakins, Julia; Hutton, Craig A.
Tetrahedron Letters, 2013 , vol. 54, # 7 p. 618 - 620
反应条件
zinc trifluoromethanesulfonate in chloroform T=68°C; 18 h;
参考文献
Sato, Kazuo; Kozikowski, Alan P.
Tetrahedron Letters, 1989 , vol. 30, # 31 p. 4073 - 4076
反应条件
1: 96 percent / LiOH / H2O; dioxane 2: 19 percent / BF3*Et2O / acetone; cyclohexane / 12 h 3: 71 percent / CuBr*Me2S / toluene / 4 h / -40 °C 4: trifluoroacetic acid View Scheme
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
