1-(2,2,2-三氟乙酰基)-4-哌啶羧酸合成路线 （共 7 条）
反应条件
in dichloromethane T=0°C;
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; WANG, Xueqing; MEYER, Michael; YAO, Betty; GUO, Tao; WEI, Guo Ping,Robert; WANG, Lijuan, Jane
Patent: WO2013/10453 A1, 2013 ;
Location in patent: Page/Page column 109 ;
反应条件
triethylamine in dichloromethane 1 h; Ambient temperature;
参考文献
Hibert; Hoffmann; Miller; Carr
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1594 - 1600
反应条件
1: SOCl2 / Heating 2: AlCl3 / 4 h / Heating View Scheme
参考文献
Palani; Shapiro; Clader; Greenlee; Cox; Strizki; Endres; Baroudy
Journal of Medicinal Chemistry, 2001 , vol. 44, # 21 p. 3339 - 3342
反应条件
1: SOCl2 / Heating 2: AlCl3 / 4 h / Heating 3: p-TsOH / Heating View Scheme
参考文献
Palani; Shapiro; Clader; Greenlee; Cox; Strizki; Endres; Baroudy
Journal of Medicinal Chemistry, 2001 , vol. 44, # 21 p. 3339 - 3342
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C 2: sodium hydroxide / ethanol / 2 h / 20 °C View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; WANG, Xueqing; MEYER, Michael; YAO, Betty; GUO, Tao; WEI, Guo Ping,Robert; WANG, Lijuan, Jane
Patent: WO2013/10453 A1, 2013 ;
反应条件
1: thionyl chloride / 2 h / Heating 2: 0.7 g / CHCl3 / 2 h / Ambient temperature 3: 200 mg / 10percent aq. NaOH / 2 h / Ambient temperature View Scheme
参考文献
Ismaiel; De los Angeles; Teitler; Ingher; Glennon
Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2519 - 2525
反应条件
1: 74 percent / H2SO4 / CHCl3 / 72 h / 40 °C 2: 72 percent / K2CO3 / methanol; H2O / 4 h / 20 °C View Scheme
参考文献
Gao, Jianxin; Wang, Poguang; Giese, Roger W.
Analytical Chemistry, 2002 , vol. 74, # 24 p. 6397 - 6401
