(R)-2-氯-1-(4-氟苯基)乙醇合成路线 （共 7 条）
反应条件
1: With borane-THF; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole in tetrahydrofuran T=20°C; 105 h; Inert atmosphere; 2: With methanol in tetrahydrofuran Inert atmosphere;
参考文献
WO2009/105220 A1, ;
Page/Page column 48 ;
WO 2009/105220 A1
反应条件
benzo[1,3,2]dioxaborole; chiral boron-bis(oxazoline) derivative in dichloromethane T=25°C; 48 h;
参考文献
European Journal of Organic Chemistry, , # 20 p. 4596 - 4608
反应条件
Pseudomonas sp. lipase in toluene T=60°C; 5 h; Enzymatic reaction; Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 67, # 25 p. 9006 - 9010
反应条件
in diethyl ether 48 h; Ambient temperatureamano lipase P from Pseudomonas sp.;
参考文献
Tetrahedron Asymmetry, , vol. 2, # 2 p. 113 - 122
参考文献
Tetrahedron Asymmetry, , vol. 2, # 2 p. 113 - 122
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Nieduzak; Margolin
Tetrahedron Asymmetry, 1991 , vol. 2, # 2 p. 113 - 122
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Nieduzak; Margolin
Tetrahedron Asymmetry, 1991 , vol. 2, # 2 p. 113 - 122
