3-(4-溴苯基)-3-氧丙酸甲酯合成路线 （共 8 条）
反应条件
1: carbonic acid dimethyl ester With sodium hydride T=20°C; Inert atmosphere; 2: para-bromoacetophenone 4 h; Inert atmosphereReflux;
参考文献
Balamurugan, Rengarajan; Manojveer, Seetharaman
Chemical Communications, 2011 , vol. 47, # 39 p. 11143 - 11145
反应条件
1: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=10 - 30°C; 2.5 h; 2: 4-bromo-benzoyl chloride in acetonitrile T=0 - 20°C;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/185056 A1, 2007 ;
Location in patent: Page/Page column 39-40 ;
US 20070185056 A1
反应条件
1: concentrated sulfuric acid / Eintragen des Reaktionsgemisches in Eis 2: diethyl ether View Scheme
参考文献
Reimer; Tobin
Journal of the American Chemical Society, 1941 , vol. 63, p. 2490,2493
反应条件
1: tetrachloromethane; bromine 2: methanol. KOH-solution 3: concentrated sulfuric acid / Eintragen des Reaktionsgemisches in Eis 4: diethyl ether View Scheme
参考文献
Reimer; Tobin
Journal of the American Chemical Society, 1941 , vol. 63, p. 2490,2493
反应条件
1: methanol. KOH-solution 2: concentrated sulfuric acid / Eintragen des Reaktionsgemisches in Eis 3: diethyl ether View Scheme
参考文献
Reimer; Tobin
Journal of the American Chemical Society, 1941 , vol. 63, p. 2490,2493
参考文献
Reimer; Tobin
Journal of the American Chemical Society, 1941 , vol. 63, p. 2490,2493
反应条件
1: NaBH4 / tetrahydrofuran; methanol 2: aq. conc. HCl / toluene / 0 °C View Scheme
参考文献
Yoshida, Kiyoshi; Horikoshi, Yoichiro; Eta, Masaaki; Chikazawa, Jun; Ogishima, Masayuki; Fukuda, Yohichi; Sato, Hiroki
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 2967 - 2972
反应条件
1: With sodium hydroxide in water
12 h;
2: With perchloric acid; sodium nitrite in water
T=20°C; 14 h;
参考文献
Sheremetev
Russian Chemical Bulletin, 2005 , vol. 54, # 4 p. 1057 - 1059
