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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
126645-26-9
合成路线
（共 11 条）
126645-26-9
→
反应条件
45121-22-0
N-BOC-D-氨基丁酸
反应条件
1: 12.40 g / LiBH4 / tetrahydrofuran / 1.5 h / 35 °C 2: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 3: CuCN / tetrahydrofuran; diethyl ether / 1 h / -40 °C 4: Bu4NF / tetrahydrofuran / 1 h / 4 °C 5: Jones reagent / acetone / 0.33 h View Scheme
参考文献
Travins, Jeremy M.; Etzkorn, Felicia A.
Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9389 - 9392
126645-26-9
→
反应条件
95715-87-0
(R)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere 2.1: toluene-4-sulfonic acid / toluene / 1.5 h / Reflux; Inert atmosphere 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C 4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.58 h / -78 °C 4.2: 0.08 h / -78 - 0 °C View Scheme
参考文献
Kundu, Indranil; Maitra, Ratnava; Jana, Manoranjan; Chattopadhyay, Shital K.
Synthesis, 2012 , vol. 2012, # 2 p. 304 - 310
126645-26-9
+
141-78-6
乙酸乙酯
→
反应条件
55477-80-0
2-叔丁氧羰基氨基丙烯酸甲酯
反应条件
1: ethyl acetate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; Metallation; 1 h; 2: Boc-Ser(TBDMS)OMe in tetrahydrofuran; hexane T=-78°C; Elimination; Claisen condensation; 12 h;
参考文献
Boesche, Uwe; Nubbemeyer, Udo
Tetrahedron, 1999 , vol. 55, # 22 p. 6883 - 6904
126645-26-9
→
反应条件
152491-85-5
(R)-(+)-N-(叔丁氧基羰基)-O-(叔丁基二甲基甲硅烷基)丝氨酸醇
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-15 - 20°C; 0.5 h;
参考文献
Bhowmik, Subhendu; Batra, Sanjay
European Journal of Organic Chemistry, 2013 , # 31 p. 7145 - 7151
126645-26-9
→
反应条件
108149-63-9
(R)-4-羟基甲基-2,2-二甲基噁唑啉-3-羧酸叔丁酯
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere 2: toluene-4-sulfonic acid / toluene / 1.5 h / Reflux; Inert atmosphere 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C View Scheme
参考文献
Kundu, Indranil; Maitra, Ratnava; Jana, Manoranjan; Chattopadhyay, Shital K.
Synthesis, 2012 , vol. 2012, # 2 p. 304 - 310
126645-26-9
→
反应条件
106930-51-2
N-Boc-D-亮氨醇
反应条件
1: 12.40 g / LiBH4 / tetrahydrofuran / 1.5 h / 35 °C 2: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 3: CuBr-SMe2 / tetrahydrofuran; diethyl ether / 1 h / -40 °C 4: Bu4NF / tetrahydrofuran / 1 h / 4 °C View Scheme
参考文献
Travins, Jeremy M.; Etzkorn, Felicia A.
Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9389 - 9392
126645-26-9
→
反应条件
2766-43-0
Boc-L-丝氨酸甲酯
反应条件
ammonium cerium(IV) nitrate; silica gel in tetrachloromethane; isopropyl alcohol desilylation; 4 h; Heating;
参考文献
Hwu, Jih Ru; Jain, Moti L.; Tsai, Fu-Yuan; Tsay, Shwu-Chen; Balakumar, Arumugham; Hakimelahi, Gholam H.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5077 - 5088
126645-26-9
→
反应条件
18942-49-9
Boc-D-苯丙氨酸
反应条件
1: 12.40 g / LiBH4 / tetrahydrofuran / 1.5 h / 35 °C 2: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 3: CuBr-SMe2 / tetrahydrofuran; diethyl ether / 1 h / -40 °C 4: Bu4NF / tetrahydrofuran / 1 h / 4 °C 5: Jones reagent / acetone / 0.33 h View Scheme
参考文献
Travins, Jeremy M.; Etzkorn, Felicia A.
Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9389 - 9392
126645-26-9
→
反应条件
106454-69-7
N-Boc-D-苯丙氨醇
反应条件
1: 12.40 g / LiBH4 / tetrahydrofuran / 1.5 h / 35 °C 2: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 3: CuBr-SMe2 / tetrahydrofuran; diethyl ether / 1 h / -40 °C 4: Bu4NF / tetrahydrofuran / 1 h / 4 °C View Scheme
参考文献
Travins, Jeremy M.; Etzkorn, Felicia A.
Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9389 - 9392
126645-26-9
→
反应条件
150736-71-3
N-Boc-(R)-(+)-2-氨基-1-丁醇
反应条件
1: 12.40 g / LiBH4 / tetrahydrofuran / 1.5 h / 35 °C 2: 68 percent / PPh3, diisopropylazodicarboxylate / tetrahydrofuran; acetonitrile / 24 h / Ambient temperature 3: CuCN / tetrahydrofuran; diethyl ether / 1 h / -40 °C 4: Bu4NF / tetrahydrofuran / 1 h / 4 °C View Scheme
参考文献
Travins, Jeremy M.; Etzkorn, Felicia A.
Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9389 - 9392
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