2-氨基-4,6-二氟苯甲酸合成路线 （共 25 条）
反应条件
1: With sodium hydroxide; dihydrogen peroxide in water T=0 - 20°C; 20 h; 2: With formic acid in water pH=3;
参考文献
Gruenenthal GmbH
Patent: US2008/293749 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
1: With sulfuric acid T=50 - 100°C; 2 h; 2: With dihydrogen peroxide; sodium hydroxide T=0 - 20°C; 3: With hydrogenchloride in water pH=1;
参考文献
JANSSEN PHARMACEUTICA NV; MEERPOEL, Lieven; MAES, Louis, Jules, Roger, Marie; DE WIT, Kelly
Patent: WO2012/69380 A1, 2012 ;
Location in patent: Page/Page column 43 ;
反应条件
1: With sulfuric acid; water T=100°C; 15 h; 2: With sodium hydroxide in water T=20°C; 3: With hydrogenchloride in water
参考文献
WO2006/64217 A2, ;
Page/Page column 52-53 ;
WO 2006/064217 A2
反应条件
1.1: sodium sulfate / water / 1.33 h / 45 - 50 °C / Large scale reaction 1.2: 0.33 h / 50 - 55 °C / Large scale reaction 1.3: 8 h / 55 °C / Large scale reaction 2.1: sulfuric acid / water / 6.5 h / 58 - 62 °C / Large scale reaction 3.1: sodium hydroxide / water / 0.67 h / 25 °C / Large scale reaction 3.2: 2.5 h / 20 - 25 °C / Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 5 p. 1078 - 1087
反应条件
piperidine in methanol T=70°C; 24 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/64217 A2, 2006 ;
Location in patent: Page/Page column 52-53 ;
WO 2006/064217 A2
反应条件
1: 87 percent / PPh3; DEAD / CH2Cl2 / 1 h / 20 °C 2: 76 percent / 2-methoxy-ethanol / 10 h / Heating View Scheme
参考文献
Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488
反应条件
1.1: 1-methyl-pyrrolidin-2-one / tert-butyl methyl ether / Large scale reaction 1.2: 1 h / 3 °C / Large scale reaction 1.3: 2.58 h / 2 °C / Large scale reaction 2.1: N-ethyl-N,N-diisopropylamine / V methoxymethyl ester; toluene / 40 - 123 °C / Large scale reaction View Scheme
参考文献
Ford, J. Gair; Pointon, Simon M.; Powell, Lyn; Siedlecki, Paul S.; Baum, John; Chubb, Richard; Fieldhouse, Robin; Muxworthy, James; Nivlet, Alex; Stenson, Rachel; Warwick, Eleanor
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1078 - 1087
参考文献
Societe de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6815546 B2, 2004 ;
参考文献
Societe de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6815546 B2, 2004 ;
参考文献
Societe de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6815546 B2, 2004 ;
