(5R,6R,7S,8R)-6,7,8-三(苄氧基)-5-[(苄氧基)甲基]-4-氧杂-1,2-二氮杂螺[2.5]辛-1-烯合成路线 （共 10 条）
反应条件
in dichloromethane T=25°C; 3 h; Yield given. Yields of byproduct given;
参考文献
Vasella; Witzig; Waldraff; Uhlmann; Briner; Bernet; Panza; Husi
Helvetica Chimica Acta, 1993 , vol. 76, # 8 p. 2847 - 2875
反应条件
in dichloromethane T=25°C; 3 h; Yield given. Yields of byproduct given;
参考文献
Vasella; Witzig; Waldraff; Uhlmann; Briner; Bernet; Panza; Husi
Helvetica Chimica Acta, 1993 , vol. 76, # 8 p. 2847 - 2875
反应条件
in dichloromethane T=25°C; 3 h; Yield given. Yields of byproduct given;
参考文献
Vasella; Witzig; Waldraff; Uhlmann; Briner; Bernet; Panza; Husi
Helvetica Chimica Acta, 1993 , vol. 76, # 8 p. 2847 - 2875
反应条件
in dichloromethane 5 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Helvetica Chimica Acta, , vol. 72, p. 1371 - 1382
反应条件
T=-70°C; 1 h; Irradiation; Yield given. Yields of byproduct given;
参考文献
Helvetica Chimica Acta, , vol. 75, # 2 p. 621 - 637
反应条件
in dichloromethane 6 h; competition reaction with 4-methoxyphenol and 4-nitrophenol;
参考文献
Briner, Karin; Vasella, Andrea
Helvetica Chimica Acta, 1990 , vol. 73, # 6 p. 1764 - 1779
反应条件
<b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '3587194', constants.ctx, '0')">iodine</a>; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=-45°C; <br />
参考文献
Briner, Karin; Vasella, Andrea Helvetica Chimica Acta, 1990 , vol. 73, # 6 p. 1764 - 1779
反应条件
<b>Multi-step reaction with 7 steps<br /> </b>1: sodium hydride / 120 °C<br />2: sulfuric acid; acetic acid / 90 °C<br />3: ethanol; hydroxylamine hydrochloride; sodium / 74 °C<br />4: sodium periodate; sodium acetate / ethanol; water / 60 °C<br />5: triethylamine / dichloromethane / 0 °C<br />6: ammonia / methanol / 20 °C<br />7: iodine; triethylamine / methanol / -20 °C<br /> <br />
参考文献
Yamada, Michio; Someya, Chika I.; Nakahodo, Tsukasa; Maeda, Yutaka; Tsuchiya, Takahiro; Akasaka, Takeshi Molecules, 2011 , vol. 16, # 11 p. 9495 - 9504
反应条件
<b>Multi-step reaction with 5 steps<br /> </b>1: ethanol; hydroxylamine hydrochloride; sodium / 74 °C<br />2: sodium periodate; sodium acetate / ethanol; water / 60 °C<br />3: triethylamine / dichloromethane / 0 °C<br />4: ammonia / methanol / 20 °C<br />5: iodine; triethylamine / methanol / -20 °C<br /> <br />
参考文献
Yamada, Michio; Someya, Chika I.; Nakahodo, Tsukasa; Maeda, Yutaka; Tsuchiya, Takahiro; Akasaka, Takeshi Molecules, 2011 , vol. 16, # 11 p. 9495 - 9504
反应条件
<b>Multi-step reaction with 7 steps<br /> </b>1: sodium hydride / 120 °C<br />2: sulfuric acid; acetic acid / 90 °C<br />3: ethanol; hydroxylamine hydrochloride; sodium / 74 °C<br />4: sodium periodate; sodium acetate / ethanol; water / 60 °C<br />5: triethylamine / dichloromethane / 0 °C<br />6: ammonia / methanol / 20 °C<br />7: iodine; triethylamine / methanol / -20 °C<br /> <br />
参考文献
Yamada, Michio; Someya, Chika I.; Nakahodo, Tsukasa; Maeda, Yutaka; Tsuchiya, Takahiro; Akasaka, Takeshi Molecules, 2011 , vol. 16, # 11 p. 9495 - 9504
