1.1: 55 percent / LiCl / dimethylsulfoxide / 2 h / Heating 2.1: H2 / Pd/C / ethanol / 18 h / 20 °C 3.1: 0.42 g / pyridine / 18 h / 20 °C 4.1: trimethylsilyl triflate 4.2: 49 percent / acetonitrile / 5 h / Heating 5.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 2 h / Heating 5.2: 55 percent / NH3 / methanol / 24 h / 20 °C View Scheme

1: 88 percent / H2 / 10percent Pd/C / ethanol / 72 h / Ambient temperature 2: 81 percent / pyridine / 12 h / Ambient temperature 3: NaN3 / dimethylsulfoxide / 1 h / 180 °C 4: pyridine / 12 h / Ambient temperature 5: 58 percent / TMS-Tfl, bis(trimethylsilyl)thymine / acetonitrile / 3 h / Heating 6: 68 percent / ammonia / methanol / 48 h View Scheme

Multi-step reaction with 5 steps 1.1: 55 percent / LiCl / dimethylsulfoxide / 2 h / Heating2.1: H2 / Pd/C / ethanol / 18 h / 20 °C3.1: 0.42 g / pyridine / 18 h / 20 °C4.1: TMS-X4.2: 56 percent / SnCl4 / acetonitrile / 5 h / Heating5.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 16 h / Heating5.2: 31 percent / NH3 / methanol / 48 h / 20 °C  

Multi-step reaction with 5 steps 1.1: 55 percent / LiCl / dimethylsulfoxide / 2 h / Heating2.1: H2 / Pd/C / ethanol / 18 h / 20 °C3.1: 0.42 g / pyridine / 18 h / 20 °C4.1: TMS-X4.2: 66 percent / SnCl4 / acetonitrile; 1,2-dichloro-ethane / 5 h / Heating5.1: tributyltin hydride; α,α'-azobisisobutyronitrile / dioxane / 6 h / Heating5.2: 79 percent / NH3 / methanol / 48 h / 20 °C  

Multi-step reaction with 3 steps 1: 39.8 percent / dibenzo-18-crown-6 / dimethylsulfoxide / 4 h / 205 - 210 °C2: 98 percent / H2 / 10percent Pd/C / ethanol / 72 h / Ambient temperature3: 81 percent / pyridine / 12 h / Ambient temperature