1-(氰基甲基)-1H-吲哚-2-羧酸乙酯合成路线 （共 4 条）
反应条件
1: ethyl 1H-indole-2-carboxylate With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: alpha-bromoacetonitrile in N,N-dimethyl-formamide T=60 - 65°C; 0.5 h;
参考文献
Universita Degli Studi Di Siena
Patent: US2009/238761 A1, 2009 ;
Location in patent: Page/Page column 26; 20 ;
US 20090238761 A1
反应条件
sodium hydride in N,N-dimethyl-formamide 1) 60 deg C - 65 deg C, 2) r.t.;
参考文献
Rajur; Merwade; Hendi; Basanagoudar
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 12 p. 1065 - 1068
反应条件
1: With lithium hydroxide in tetrahydrofuran; water
T=20°C; 6 h;
2: in tetrahydrofuran; water
pH=2;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2008/68159 A1, 2008 ;
Location in patent: Page/Page column 35 ;
WO 2008/068159 A1
反应条件
lithium aluminium tetrahydride in diethyl ether
Heating;
参考文献
Rajur; Merwade; Hendi; Basanagoudar
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 12 p. 1065 - 1068
