2,4-二氯吡咯并[2,3-D]嘧啶合成路线 （共 9 条）
反应条件
trichlorophosphate 18 h; Heating / reflux;
参考文献
WO2005/49033 A1, ;
Page/Page column 110 ;
WO 2005/049033 A1
反应条件
1: Heating 2: POCl3; DMF / Heating View Scheme
参考文献
Archiv der Pharmazie, , vol. 339, # 4 p. 182 - 192
反应条件
1: aqueous KMnO4 / Erwaermen des Reaktionsprodukts mit wss. HCl 2: 190 °C 3: POCl3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 77, p. 2256,2259
反应条件
sodium hydrogensulfide; water
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1955 , vol. 77, p. 2256,2259
反应条件
sodium hydroxide Ambient temperature;
参考文献
Monge, Antonio; Martinez-Merino, Victor; Sanmartin, Carmen; Fernandez, Francisco J.; Ochoa, Maria C.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 209 - 216
反应条件
1: NH3 2: ethanol 3: Raney nickel; aq. NaOH solution View Scheme
参考文献
Oakes et al.
Journal of the Chemical Society, 1956 , p. 1045,1053
反应条件
1: NH3
2: water; H2S; NaHS
3: Raney nickel; aq.-ethanolic NH3
View Scheme
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1955 , vol. 77, p. 2256,2259
反应条件
1: H2O; NaHS
2: aqueous acetic acid; sodium acetate
View Scheme
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1955 , vol. 77, p. 2256,2259
反应条件
1: NH3
2: ethanol
View Scheme
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1955 , vol. 77, p. 2256,2259
