1: With [bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=-5°C; 0.333333 h; Inert atmosphere; 2: With ethanol in dichloromethane T=20°C; 15 h;

1: diiodomethane With diethylzinc; trifluoroacetic acid in hexane; dichloromethane T=-5 - 0°C; 0.833333 h; 2: 2,2-difluoro-4-pentenoic acid ethyl ester in hexane; dichloromethane 16.42 h; CoolingReflux; Product distribution / selectivity;

1.1: N-bromosuccinmide / water; acetone / 1.5 h / -5 °C 2.1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / dichloromethane / 0.33 h / -5 °C / Inert atmosphere 2.2: 15 h / 20 °C View Scheme