water; iodine; acetic acid; ethylene dibromide in tetrahydrofuran 2.5 h; Heating / reflux;

1: acetic anhydride With perchloric acid T=-10°C; Inert atmosphere; 2: CDB-3236 in dichloromethane T=-30 - -20°C; 2 h; Inert atmosphere;

toluene-4-sulfonic acid in dichloromethane T=0°C; 0.333333 h;

1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating 2: 68 percent / p-TsOH / CH2Cl2 / 0.33 h / 0 °C View Scheme

1.1: triethylamine; acetic acid / |Inert atmosphere 2.1: sodium methylate / methanol 3.1: |Acidic conditions 4.1: perchloric acid / -10 °C / |Inert atmosphere 4.2: 2 h / -30 - -20 °C / |Inert atmosphere View Scheme

1.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C 2.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 2.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 3.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating 4.1: 68 percent / p-TsOH / CH2Cl2 / 0.33 h / 0 °C View Scheme

1.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 1.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 2.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating 3.1: 68 percent / p-TsOH / CH2Cl2 / 0.33 h / 0 °C View Scheme

1.1: Li; di-t-butyl biphenyl / tetrahydrofuran / 2.25 h / -70 °C 1.2: HC(OEt)3; p-TsOH / CH2Cl2 / 20 °C 2.1: 54.3 percent / 30 percent H2O2; (CF3)2CO*3H2O; Na2HPO4 / CH2Cl2 / 7.5 h / 4 °C 3.1: Mg; I2; dibromoethane / tetrahydrofuran / 1.5 h 3.2: 76 percent / CuCl / tetrahydrofuran / 1 h / 20 °C 4.1: 88 percent / aq. H2SO4 / ethanol / 1 h / Heating 5.1: 68 percent / p-TsOH / CH2Cl2 / 0.33 h / 0 °C View Scheme

1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / |Inert atmosphere 1.2: 1 h / 0 °C / |Inert atmosphere 2.1: triethylamine; acetic acid / |Inert atmosphere 3.1: sodium methylate / methanol 4.1: |Acidic conditions 5.1: perchloric acid / -10 °C / |Inert atmosphere 5.2: 2 h / -30 - -20 °C / |Inert atmosphere View Scheme

1.1: magnesium; iodine / tetrahydrofuran / 20 - 50 °C / |Inert atmosphere 1.2: 1 h / 0 °C / |Inert atmosphere 2.1: triethylamine; acetic acid / |Inert atmosphere 3.1: sodium methylate / methanol 4.1: |Acidic conditions 5.1: perchloric acid / -10 °C / |Inert atmosphere 5.2: 2 h / -30 - -20 °C / |Inert atmosphere View Scheme