1.1: potassium hydroxide; ethanol / 15 - 25 °C 2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 3.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 4.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 4.2: 25 - 30 °C 4.3: 10 - 15 °C 5.1: hydrogen; acetic acid / palladium 10 on activated carbon / 25 °C / 724.03 Torr 5.2: 10 °C / pH 7.5 - 8.5 View Scheme

1.1: potassium hydroxide; ethanol / 15 - 25 °C 2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 3.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 4.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 4.2: 25 - 30 °C 4.3: 10 - 15 °C 5.1: hydrogen; acetic acid / palladium 10 on activated carbon / 25 °C / 724.03 Torr 5.2: 10 °C / pH 7.5 - 8.5 6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme

1: potassium hydroxide; ethanol / 15 - 25 °C 2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C View Scheme

1: potassium hydroxide; ethanol / 15 - 25 °C 2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 3: potassium hydroxide / methanol / 8 h / 60 - 65 °C View Scheme