1-(4-吡啶)-4-哌啶酮合成路线 （共 5 条）
反应条件
hydrogenchloride in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Roche Diagnostics GmbH
Patent: US2003/236266 A1, 2003 ;
Location in patent: Page 7 ;
反应条件
sodium hydroxide; sodium acetate; pyridinium chlorochromate in dichloromethane
参考文献
US6403595 B1, ;
US 6403595 B1
反应条件
1: 76 percent / NaO-t-Bu; X-Phos / Pd(OAc)2 / toluene; 2-methyl-propan-2-ol / 8 h / 120 °C 2: 75 percent / HCl / 100 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 14 p. 2519 - 2525
反应条件
1: 76 percent / NaO-t-Bu; X-Phos / Pd(OAc)2 / toluene; 2-methyl-propan-2-ol / 8 h / 120 °C 2: 75 percent / HCl / 100 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 48, # 14 p. 2519 - 2525
反应条件
1: Et3N / ethanol / 22 h / 150 °C 2: 6.1 g / aq. HCl / 0.17 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3586 - 3604
