1: With thionyl chloride in dichloromethane T=20°C; 2: With potassium carbonate in water pH=9;

1.1: n-heptane; ethylene glycol dimethyl ether / 3 h / 20 °C 2.1: trichlorophosphate / 85 - 90 °C 2.2: pH 9 3.1: zinc / tris-(dibenzylideneacetone)dipalladium(0); [Fe(II)(C5H5)(C5H4PPh2)] / isobutyramide / 2 h / 120 °C / Inert atmosphere 4.1: sodium hydroxide; water / ethanol / 6 h / Reflux 5.1: trichlorophosphate / Reflux 5.2: pH 9 6.1: calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 6 h / Reflux 7.1: thionyl chloride / dichloromethane / 20 °C 7.2: pH 9 View Scheme

1.1: zinc / tris-(dibenzylideneacetone)dipalladium(0); [Fe(II)(C5H5)(C5H4PPh2)] / isobutyramide / 2 h / 120 °C / Inert atmosphere 2.1: sodium hydroxide; water / ethanol / 6 h / Reflux 3.1: trichlorophosphate / Reflux 3.2: pH 9 4.1: calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 6 h / Reflux 5.1: thionyl chloride / dichloromethane / 20 °C 5.2: pH 9 View Scheme

1.1: sodium hydroxide; water / ethanol / 6 h / Reflux 2.1: trichlorophosphate / Reflux 2.2: pH 9 3.1: calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 6 h / Reflux 4.1: thionyl chloride / dichloromethane / 20 °C 4.2: pH 9 View Scheme

1.1: trichlorophosphate / Reflux 1.2: pH 9 2.1: calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 6 h / Reflux 3.1: thionyl chloride / dichloromethane / 20 °C 3.2: pH 9 View Scheme

1.1: calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 6 h / Reflux 2.1: thionyl chloride / dichloromethane / 20 °C 2.2: pH 9 View Scheme