1: (S)-tert-butyl 2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate With potassium tert-butylate in tetrahydrofuran T=-78 - 23°C; 0.5 h; 2: With diethyl chlorophosphate in tetrahydrofuran T=-10°C; 0.75 h; 3: acetic acid hydrazide in tetrahydrofuran; butan-1-ol T=23 - 90°C; 2 h;

Multi-step reaction with 3 steps 1.1: Lawesson's reagent / toluene / 4 h / |Inert atmosphere; |Reflux2.1: NH2NH2•xH2O / tetrahydrofuran / 5 h / 20 °C / |Inert atmosphere; |Cooling with ice3.1: 1-methyl-pyrrolidin-2-one; isobutyl chloroformate / tetrahydrofuran / 5 h / |Inert atmosphere; |Cooling with ice3.2: 12 h / 90 °C / |Inert atmosphere