1: 66 percent / pyridine / 1 h / 100 °C 2: 62 percent / sodium hydride (60 percent) / tetrahydrofuran / 1.5 h / Ambient temperature 3: 1.) pyridine, DMF, copper powder, 4-dimethylaminopyridine / 1.) < -70 to 115 deg C; sealed tube, 2.) 8 h, 60 deg C; sealed tube was opened 4: NaI, trimethylsilyl chloride / acetonitrile / 2 h / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: 66 percent / pyridine / 1 h / 100 °C2: 62 percent / sodium hydride (60 percent) / tetrahydrofuran / 1.5 h / Ambient temperature