1: With lithium hydroxide hydrate in methanol; water T=0°C; 24 h; 2: With sodium dihydrogenphosphate in methanol; water; ethyl acetate Saturated solution;

1.1: diethylzinc / toluene / 3 h / Reflux 1.2: 1 h 1.3: 4 h / 20 °C 2.1: zinc / methanol; water / 22 h / 20 °C 3.1: triethylamine / dichloromethane / 2.17 h / -78 - 20 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.83 h / -10 °C 5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.08 h / 20 °C 6.1: (NH4)6[Mo7O24]*4H2O; dihydrogen peroxide / ethanol; water / 3 h / 20 °C 7.1: 1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2Λ54Λ5-catenadi(phosphazene) / hexane; acetonitrile / 2.08 h / -40 - 20 °C 8.1: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / -20 °C 8.2: -20 - 20 °C 9.1: sodium chlorite; sodium dihydrogenorthophosphate / 2-methyl-but-2-ene; water; tert-butyl alcohol / 0 - 20 °C 10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C View Scheme

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran; diethyl ether; dimethyl sulfoxide / 0 - 20 °C 2.1: diethylzinc / toluene / 3 h / Reflux 2.2: 1 h 2.3: 4 h / 20 °C 3.1: zinc / methanol; water / 22 h / 20 °C 4.1: triethylamine / dichloromethane / 2.17 h / -78 - 20 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.83 h / -10 °C 6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.08 h / 20 °C 7.1: (NH4)6[Mo7O24]*4H2O; dihydrogen peroxide / ethanol; water / 3 h / 20 °C 8.1: 1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2Λ54Λ5-catenadi(phosphazene) / hexane; acetonitrile / 2.08 h / -40 - 20 °C 9.1: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / -20 °C 9.2: -20 - 20 °C 10.1: sodium chlorite; sodium dihydrogenorthophosphate / 2-methyl-but-2-ene; water; tert-butyl alcohol / 0 - 20 °C 11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C View Scheme

1.1: hydrogen / hexane 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane 3.1: benzene / 70 °C 4.1: chromium dichloride / tetrahydrofuran / 0 °C 5.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / benzene / 20 °C 6.1: pyridinium p-toluenesulfonate / methanol / 0 °C 7.1: copper/silver activated zinc; water / methanol / 16 h / 40 - 45 °C 8.1: lithium hydroxide hydrate / methanol; water / 24 h / 0 °C 8.2: Saturated solution View Scheme

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane 2.1: benzene / 70 °C 3.1: chromium dichloride / tetrahydrofuran / 0 °C 4.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / benzene / 20 °C 5.1: pyridinium p-toluenesulfonate / methanol / 0 °C 6.1: copper/silver activated zinc; water / methanol / 16 h / 40 - 45 °C 7.1: lithium hydroxide hydrate / methanol; water / 24 h / 0 °C 7.2: Saturated solution View Scheme

1.1: benzene / 70 °C 2.1: chromium dichloride / tetrahydrofuran / 0 °C 3.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / benzene / 20 °C 4.1: pyridinium p-toluenesulfonate / methanol / 0 °C 5.1: copper/silver activated zinc; water / methanol / 16 h / 40 - 45 °C 6.1: lithium hydroxide hydrate / methanol; water / 24 h / 0 °C 6.2: Saturated solution View Scheme

1.1: chromium dichloride / tetrahydrofuran / 0 °C 2.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / benzene / 20 °C 3.1: pyridinium p-toluenesulfonate / methanol / 0 °C 4.1: copper/silver activated zinc; water / methanol / 16 h / 40 - 45 °C 5.1: lithium hydroxide hydrate / methanol; water / 24 h / 0 °C 5.2: Saturated solution View Scheme

1.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / benzene / 20 °C 2.1: pyridinium p-toluenesulfonate / methanol / 0 °C 3.1: copper/silver activated zinc; water / methanol / 16 h / 40 - 45 °C 4.1: lithium hydroxide hydrate / methanol; water / 24 h / 0 °C 4.2: Saturated solution View Scheme

1.1: 1H-imidazole; iodine; triphenylphosphine / 60 °C 2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2 h / -78 °C 3.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / benzene / 20 °C 4.1: pyridinium p-toluenesulfonate / methanol / 0 °C 5.1: copper/silver activated zinc; water / methanol / 16 h / 40 - 45 °C 6.1: lithium hydroxide hydrate / methanol; water / 24 h / 0 °C 6.2: Saturated solution View Scheme

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2 h / -78 °C 2.1: piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / benzene / 20 °C 3.1: pyridinium p-toluenesulfonate / methanol / 0 °C 4.1: copper/silver activated zinc; water / methanol / 16 h / 40 - 45 °C 5.1: lithium hydroxide hydrate / methanol; water / 24 h / 0 °C 5.2: Saturated solution View Scheme