1: With N,N-dimethyl-aniline; trichlorophosphate T=100°C; Neat (no solvent); 2: With sodium hydrogencarbonate in water pH=7;

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 35 °C 2.1: hydrogen / palladium 10 on activated carbon / methanol / 30 °C 3.1: trichlorophosphate; N,N-dimethyl-aniline / 100 °C / Neat (no solvent) 3.2: pH 7 View Scheme

1.1: thionyl chloride / 3 h / 0 °C / Reflux 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 35 °C 3.1: hydrogen / palladium 10 on activated carbon / methanol / 30 °C 4.1: trichlorophosphate; N,N-dimethyl-aniline / 100 °C / Neat (no solvent) 4.2: pH 7 View Scheme

1.1: hydrogen / palladium 10 on activated carbon / methanol / 30 °C 2.1: trichlorophosphate; N,N-dimethyl-aniline / 100 °C / Neat (no solvent) 2.2: pH 7 View Scheme