1: 84 percent / KOH / ethanol; H2O / 4 h / Heating 2: 89 percent / DCC, Et3N / CH2Cl2 3: 84 percent / PPE / 1,2-dichloro-ethane 4: 71 percent / NBS / CH2Cl2 / 0.5 h / Ambient temperature 5: 64 percent / BBr3 / CH2Cl2 / 5 h / Heating View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '113916', constants.ctx, '0')">N-bromosuccinmide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102551', constants.ctx, '0')">1,4-dioxane</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a> <br />1&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 1.) H₃PO₄ / 1.) RT, 17 min, 2.) pyridine, RT<br />2: 88 percent / K₂CO₃ / methanol; acetone / 12 h / Ambient temperature<br />3: 60 percent / K₂CO₃ / acetone / 48 h / Heating<br />4: 79 percent / NBS / acetic acid; dioxane / 1 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 88 percent / K₂CO₃ / methanol; acetone / 12 h / Ambient temperature<br />2: 60 percent / K₂CO₃ / acetone / 48 h / Heating<br />3: 79 percent / NBS / acetic acid; dioxane / 1 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 60 percent / K₂CO₃ / acetone / 48 h / Heating<br />2: 79 percent / NBS / acetic acid; dioxane / 1 h / Ambient temperature<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />12&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;