3-溴-5-氯-2-氟苯胺合成路线 （共 4 条）
反应条件
trifluoroacetic acid in tetrahydrofuran; dichloromethane T=20°C; 1 h;
参考文献
IRM LLC; NOVARTIS AG; HUANG, Shenlin; JIN, Xianming; LIU, Zuosheng; POON, Daniel; TELLEW, John; WAN, Yongqin; WANG, Xing; XIE, Yongping
Patent: WO2011/25927 A1, 2011 ;
Location in patent: Page/Page column 51 ;
WO 2011/025927 A1
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 1.2: -78 - 20 °C 2.1: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 75 - 84 °C 2.2: 0.25 h / 35 °C 3.1: trifluoroacetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
IRM LLC; NOVARTIS AG; HUANG, Shenlin; JIN, Xianming; LIU, Zuosheng; POON, Daniel; TELLEW, John; WAN, Yongqin; WANG, Xing; XIE, Yongping
Patent: WO2011/25927 A1, 2011 ;
WO 2011/025927 A1
反应条件
1.1: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 75 - 84 °C 1.2: 0.25 h / 35 °C 2.1: trifluoroacetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
IRM LLC; NOVARTIS AG; HUANG, Shenlin; JIN, Xianming; LIU, Zuosheng; POON, Daniel; TELLEW, John; WAN, Yongqin; WANG, Xing; XIE, Yongping
Patent: WO2011/25927 A1, 2011 ;
WO 2011/025927 A1
反应条件
1.1: potassium permanganate / water; tert-butyl alcohol / 2.5 h / 40 - 60 °C 1.2: 1 h / 50 °C 1.3: pH 1 2.1: triethylamine; diphenylphosphoranyl azide / toluene / 2 h / 75 - 84 °C 2.2: 0.25 h / 35 °C 3.1: trifluoroacetic acid / dichloromethane; tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
IRM LLC; NOVARTIS AG; HUANG, Shenlin; JIN, Xianming; LIU, Zuosheng; POON, Daniel; TELLEW, John; WAN, Yongqin; WANG, Xing; XIE, Yongping
Patent: WO2011/25927 A1, 2011 ;
WO 2011/025927 A1
