(3S)-3-苯基-3-[4-(三氟甲基)苯氧基]-1-丙胺合成路线 （共 13 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; Resolution of racemate;
参考文献
WO2006/25920 A2, ;
Page/Page column 148-149 ;
WO 2006/025920 A2
反应条件
sodium hydride in dimethyl sulfoxide T=90 - 100°C; 1 h;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 18 p. 2039 - 2051
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=65°C; 5 h;
参考文献
Devine, Paul N.; Heid Jr., Richard M.; Tschaen, David M.
Tetrahedron, 1997 , vol. 53, # 20 p. 6739 - 6746
反应条件
ammonium hydroxide; oxalic acid in methanol; dichloromethane; isobutyramide; ethyl acetate
参考文献
US5250571 A1, ;
US 5250571 A
反应条件
hydrazine hydrate in methanol; dichloromethane T=20°C; 8 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 1 p. 337 - 343
反应条件
1: n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C 2: LiAlH4 / tetrahydrofuran / 0.5 h / -78 °C 3: Et3N / CH2Cl2 / 0.25 h 4: dimethylformamide / 0.25 h 5: 96 percent / BH3*SMe2 / tetrahydrofuran / 5 h / 65 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 20 p. 6739 - 6746
反应条件
1: Et3N / CH2Cl2 / 0.25 h 2: dimethylformamide / 0.25 h 3: 96 percent / BH3*SMe2 / tetrahydrofuran / 5 h / 65 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 20 p. 6739 - 6746
反应条件
1: LiAlH4 / tetrahydrofuran / 0.5 h / -78 °C 2: Et3N / CH2Cl2 / 0.25 h 3: dimethylformamide / 0.25 h 4: 96 percent / BH3*SMe2 / tetrahydrofuran / 5 h / 65 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 20 p. 6739 - 6746
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: sodium iodide / dimethyl sulfoxide / 13 h / 70 °C 3.1: hydrazine hydrate / methanol; dichloromethane / 8 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 1 p. 337 - 343
反应条件
1: sodium iodide / dimethyl sulfoxide / 13 h / 70 °C 2: hydrazine hydrate / methanol; dichloromethane / 8 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 1 p. 337 - 343
