(3S)-3-苯基-3-[4-(三氟甲基)苯氧基]-1-丙胺合成路线 （共 13 条）
反应条件
1: 85.2 percent / Et3N / tetrahydrofuran / 18 h / Heating 2: BH3*SMe2 / tetrahydrofuran / 2.5 h / Heating 3: 1.) NaH / 1.) DMSO, 55 deg C, 30 min, 2.) DMSO, 90 deg C, 1 h View Scheme
参考文献
Synthetic Communications, , vol. 25, # 8 p. 1231 - 1238
反应条件
1.1: sodium hydride / isobutyramide 2.1: human cytochrome P450 2C19 / 0.05 h / 37 °C / aq. phosphate buffer; Enzymatic reaction 2.2: aq. phosphate buffer View Scheme
参考文献
Drug Metabolism and Disposition, , vol. 38, # 6 p. 963 - 972
反应条件
1: T=37°C; 0.05 h; aq. phosphate bufferEnzymatic reaction; 2: With NADPH aq. phosphate buffer;
参考文献
Drug Metabolism and Disposition, , vol. 38, # 6 p. 963 - 972
