(+/-)-1-苯甲氧基羰基-4-Boc-哌嗪-2-羧酸合成路线 （共 13 条）
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 23 p. 4241 - 4244
反应条件
1: 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile; D,L-piperazine-2-carboxylic acid dihydrochloride With sodium hydroxide in 1,4-dioxane; water T=20°C; pH=11; 2: N-(benzyloxycarbonyloxy)-succinimide in 1,4-dioxane; water T=0 - 20°C; pH=10; 3: With hydrogenchloride in diethyl ether; water pH=1;
参考文献
WO2010/23480 A1, ;
Page/Page column 43-44 ;
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Warner-Lambert
Patent: US6251919 B1, 2001 ;
US 6251919 B1
反应条件
1: aq. NaOH / dioxane 2: dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 23 p. 4241 - 4244
反应条件
1: aq. NaOH / dioxane 2: dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 23 p. 4241 - 4244
反应条件
1: With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=-15°C; 0.166667 h; 2: With ammonium hydroxide; hydrogen in tetrahydrofuran T=0°C; 2 h; 3: With palladium on activated carbon in methanol 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENEKA UK LIMITED
Patent: WO2005/26156 A1, 2005 ;
Location in patent: Page/Page column 124-125 ;
WO 2005/026156 A1
反应条件
1: With boron trifluoride diethyl etherate in dichloromethane; cyclohexane T=0 - 20°C; 0.75 h; 2: With sodium hydrogencarbonate in dichloromethane; cyclohexane
参考文献
CHROMA THERAPEUTICS LTD.
Patent: WO2008/50096 A1, 2008 ;
Location in patent: Page/Page column 48-49 ;
WO 2008/050096 A1
反应条件
potassium carbonate in acetone 6 h; Reflux;
参考文献
WO2010/23480 A1, ;
Page/Page column 44 ;
反应条件
potassium carbonate in acetone T=60°C; 18 h;
参考文献
WO2005/79799 A1, ;
Page/Page column 17 ;
WO 2005/079799 A1
反应条件
in methanol; hexane; acetic acid; benzene
