反应条件
1.1: bromine / acetic acid / 8 h / 100 °C 1.2: 20 °C 2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 3 h / 120 °C / 15514.9 Torr / Autoclave 3.1: trichlorophosphate / 2 h / Reflux 3.2: Cooling with ice 4.1: water; lithium hydroxide hydrate / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Mathieu, Simon; Gradl, Stefan N.; Ren, Li; Wen, Zhaoyang; Aliagas, Ignacio; Gunzner-Toste, Janet; Lee, Wendy; Pulk, Rebecca; Zhao, Guiling; Alicke, Bruno; Boggs, Jason W.; Buckmelter, Alex J.; Choo, Edna F.; Dinkel, Victoria; Gloor, Susan L.; Gould, Stephen E.; Hansen, Joshua D.; Hastings, Gregg; Hatzivassiliou, Georgia; Laird, Ellen R.; Moreno, David; Ran, Yingqing; Voegtli, Walter C.; Wenglowsky, Steve; Grina, Jonas; Rudolph, Joachim
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2869 - 2881