8-(4-氯苯基)-1,4-二氧杂螺[4.5]癸烷-8-醇合成路线 （共 11 条）
反应条件
1: 1-chloro-4-bromobenzene With magnesium; iodine in tetrahydrofuran T=50°C; Inert atmosphere; 2: 1,4-cyclohexanedione monoacetal in tetrahydrofuran T=40 - 50°C; 1 h;
参考文献
WO2012/153162 A1, ;
Page/Page column 36 ;
反应条件
tert.-butyl lithium in tetrahydrofuran T=-60°C;
参考文献
Tetrahedron Letters, , vol. 39, # 42 p. 7629 - 7632
反应条件
n-butyllithium in tetrahydrofuran T=-78°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4910 - 4914
反应条件
pyridinium p-toluenesulfonate in water; acetone Heating;
参考文献
Williams, David R.; Clark, Michael P.
Tetrahedron Letters, 1998 , vol. 39, # 42 p. 7629 - 7632
反应条件
1: TsOH / benzene / Heating 2: H2 / Pd/C / ethyl acetate / 3 h View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 41 p. 17023 - 17026
反应条件
diphosphorous tetraiodide
参考文献
Williams, David R.; Clark, Michael P.
Tetrahedron Letters, 1998 , vol. 39, # 42 p. 7629 - 7632
反应条件
toluene-4-sulfonic acid in ethylene glycol; toluene T=110°C; 6 h;
参考文献
WO2012/153162 A1, ;
Page/Page column 37 ;
反应条件
1: TsOH / benzene / Heating 2: H2 / Pd/C / ethyl acetate / 3 h 3: TsOH / acetone / 60 °C View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 41 p. 17023 - 17026,4
反应条件
diphosphorous tetraiodide
参考文献
Williams, David R.; Clark, Michael P.
Tetrahedron Letters, 1998 , vol. 39, # 42 p. 7629 - 7632
反应条件
toluene-4-sulfonic acid in toluene
Heating;
参考文献
Ekkati, Anil R.; Mandiyan, Valsan; Ravindranathan, Krishna P.; Bae, Jae H.; Schlessinger, Joseph; Jorgensen, William L.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2228 - 2231
