8-(4-氯苯基)-1,4-二噁螺[4.5]-7-癸烯合成路线 （共 5 条）
反应条件
toluene-4-sulfonic acid in ethylene glycol; toluene T=110°C; 6 h;
参考文献
WO2012/153162 A1, ;
Page/Page column 37 ;
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux 1.2: 20 °C / |Reflux 2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 41 p. 17023 - 17026,4
反应条件
1.1: magnesium / tetrahydrofuran / |Reflux 1.2: 20 °C / |Reflux 2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 41 p. 17023 - 17026,4
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 3 h;
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 20208 - 20208
反应条件
1: H2 / Pd/C / ethyl acetate / 3 h 2: TsOH / acetone / 60 °C View Scheme
参考文献
Zhou, Lin; Liu, Xiaohua; Ji, Jie; Zhang, Yuheng; Hu, Xiaolei; Lin, Lili; Feng, Xiaoming
Journal of the American Chemical Society, 2012 , vol. 134, # 49 p. 20208 - 20208
