(2R,3S)-2-铵基-3-羟基-2-甲基丁酸酯合成路线 （共 5 条）
反应条件
1: With tert-butylhypochlorite in diethyl ether T=0 - 20°C; 2 h; 2: With triethylamine in diethyl ether T=0 - 20°C; 20 h; 3: With hydrogenchloride T=0 - 80°C; 72 h;
参考文献
Watts, John; Benn, Alex; Flinn, Nick; Monk, Tracy; Ramjee, Manoj; Ray, Peter; Wang, Yikang; Quibell, Martin
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2903 - 2925
反应条件
1: n-Bu4NBH4 / methanol / -78 °C 2: 88 percent / triflic anhydride; 2,6-di-tert-butyl-4-methylpyridine / CH2Cl2 / 0.08 h / 0 °C 3: HCl / tetrahydrofuran; H2O / 2 h / 25 °C 4: Jones reagent / acetone / 6 h / 0 - 25 °C 5: 42 mg / HCl / H2O / 48 h / 100 °C View Scheme
参考文献
Avenoza, Alberto; Busto, Jesus H.; Corzana, Francisco; Peregrina, Jesus M.; Sucunza, David; Zurbano, Maria M.
Tetrahedron Asymmetry, 2004 , vol. 15, # 4 p. 719 - 724
反应条件
1.1: IPy2BF4 / acetonitrile / 12 h / -40 °C 1.2: LiAlH4 / tetrahydrofuran / 25 °C 2.1: HCl / tetrahydrofuran; H2O / 2 h / 25 °C 3.1: Jones reagent / acetone / 6 h / 0 - 25 °C 4.1: 42 mg / HCl / H2O / 48 h / 100 °C View Scheme
参考文献
Avenoza, Alberto; Busto, Jesus H.; Corzana, Francisco; Peregrina, Jesus M.; Sucunza, David; Zurbano, Maria M.
Tetrahedron Asymmetry, 2004 , vol. 15, # 4 p. 719 - 724
反应条件
1: HCl / tetrahydrofuran; H2O / 2 h / 25 °C 2: Jones reagent / acetone / 6 h / 0 - 25 °C 3: 42 mg / HCl / H2O / 48 h / 100 °C View Scheme
参考文献
Avenoza, Alberto; Busto, Jesus H.; Corzana, Francisco; Peregrina, Jesus M.; Sucunza, David; Zurbano, Maria M.
Tetrahedron Asymmetry, 2004 , vol. 15, # 4 p. 719 - 724
反应条件
1: With hydrogenchloride; water 24 h; Reflux; 2:
参考文献
Dietz, Friedrich R.; Groeger, Harald
Synthesis, 2009 , # 24 art. no. T08709SS, p. 4208 - 4218
