1: 90 percent / HCl-EtOH / ethyl acetate / 0.5 h / 10 - 15 °C 2: 75 percent / ammonia / methanol / 22 h / Ambient temperature; pH 12 View Scheme

hydrogenchloride in ethyl acetate T=10 - 15°C; 0.5 h;

Multi-step reaction with 2 steps 1: 63 percent / LiI / ethyl acetate / 2.5 h / Heating2: 94 percent / triethylamine / Pd/C / 1,2-dimethoxy-ethane / 1.25 h / 1810.02 Torr  

Multi-step reaction with 3 steps 1: 87 percent / pyridine / 1.5 h / Ambient temperature2: 63 percent / LiI / ethyl acetate / 2.5 h / Heating3: 94 percent / triethylamine / Pd/C / 1,2-dimethoxy-ethane / 1.25 h / 1810.02 Torr