(R)-2-叔丁氧羰基氨基-3-环己基丙酸合成路线 （共 3 条）
反应条件
potassium carbonate in tetrahydrofuran; water T=20°C; pH=10 - 11;
参考文献
Reid, Robert C.; Abbenante, Giovanni; Taylor, Stephen M.; Fairlie, David P.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4464 - 4471
反应条件
triethylamine in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3181 - 3184
反应条件
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 760.05 Torr / |Inert atmosphere
1.2: 18 h / 760.05 Torr / |Inert atmosphere
2.1: trifluoroacetic acid / 2 h / 760.05 Torr / |Inert atmosphere
View Scheme
参考文献
PORTOLA PHARMACEUTICALS, INC.; SONG, Yonghong; XU, Qing; SRAN, Arvinder; BAUER, Shawn M.; JIA, Zhaozhong J.; KANE, Brian; PANDEY, Anjali
Patent: WO2013/192046 A2, 2013 ;
