1.1: sodium hydroxide; water / ethanol / 3 h / 60 °C 2.1: 4-(N,N-dimethlyamino)pyridine; 4-methyl-morpholine; HATU / acetonitrile / 5.75 h / 20 - 50 °C 3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C 4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C 4.2: 72 h 5.1: acetic acid / 4 h / 35 °C 5.2: 6 h / 60 °C View Scheme