1: 96 percent / HCl / dioxane / 2 h / Ambient temperature 2: 13.5 percent / Et3N / CH2Cl2 / 1.) -60 deg C, 30 min, 2.) 10 deg C, 1 h 3: 14 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 73.9 percent / 1-&lt;3-(dimethylamino)propyl&gt;-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / 20 h / Ambient temperature<br />2: 91 percent / HCl / dioxane / 2 h / Ambient temperature<br />3: 72 percent / 1-&lt;3-(dimethylamino)propyl&gt;-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / 24 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 99 percent / NaOH / ethanol / Ambient temperature<br />2: 73.9 percent / 1-&lt;3-(dimethylamino)propyl&gt;-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / 20 h / Ambient temperature<br />3: 91 percent / HCl / dioxane / 2 h / Ambient temperature<br />4: 72 percent / 1-&lt;3-(dimethylamino)propyl&gt;-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / 24 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 85 percent / Et₃N / methanol; tetrahydrofuran / 20 h / Ambient temperature<br />2: 72 percent / 1-&lt;3-(dimethylamino)propyl&gt;-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / 24 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 85 percent / Et₃N / methanol; tetrahydrofuran / 20 h / Ambient temperature<br />2: 72 percent / 1-&lt;3-(dimethylamino)propyl&gt;-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / 24 h / Ambient temperature<br /> <br /> &nbsp;