hydrogenchloride T=22°C; rate of hydrolysis relative to dideoxyadenosine;

<b>Multi-step reaction with 7 steps<br /> </b>1: 92 percent / dimethylformamide / 2 h / Ambient temperature<br />2: 78 percent / N,N-dimethylaminopyridine, NEt₃ / dimethylformamide; CH₂Cl₂ / 12 h / Ambient temperature<br />3: 87 percent / dimethylformamide / 6 h / Ambient temperature<br />4: 61 percent / tributyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 2.5 h / Heating<br />5: 76 percent / dimethylformamide / 5 h / 90 &deg;C<br />6: 47 percent / tributyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 1.5 h / Heating<br />7: 74 percent / Et₄NF / acetonitrile / 3 h / Ambient temperature<br /> <br /> &nbsp;