5-甲氧基-2,3二氢-1H吲哚合成路线 （共 7 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0°C; 16 h; Heating / reflux; 2: With hydrogenchloride in tetrahydrofuran; methanol; water 3 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44045 A1, 2008 ;
Location in patent: Page/Page column 277-279 ;
WO 2008/044045 A1
反应条件
Pd(OH)2/C; ammonium formate in methanol Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 14 p. 4204 - 4209
反应条件
hydrogen bromide; phenol in propan-1-ol; water T=100°C; 2 h;
参考文献
EP1595866 A1, ;
Page/Page column 28 ;
参考文献
US2008/214542 A1, ;
Page/Page column 9 ;
反应条件
1: 80 percent / aq. HBr / 2 h / 100 °C 2: 40 percent / Et3N / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Austin, Nigel E; Avenell, Kim Y; Boyfield, Izzy; Branch, Clive L; Hadley, Michael S; Jeffrey, Phillip; Johnson, Christopher N; Macdonald, Gregor J; Nash, David J; Riley, Graham J; Smith, Alexander B; Stemp, Geoffrey; Thewlis, Kevin M; Vong, Antonio K.K; Wood, Martyn D
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 685 - 688
反应条件
1: 80 percent / aq. HBr / 2 h / 100 °C 2: 40 percent / Et3N / CH2Cl2 / 16 h / 20 °C 3: 70 percent / Et3N / CH2Cl2 / 6 h / -20 - 20 °C 4: 90 percent / Pd(PPh3)4 / dimethylformamide / 4 h / 100 °C View Scheme
参考文献
Austin, Nigel E; Avenell, Kim Y; Boyfield, Izzy; Branch, Clive L; Hadley, Michael S; Jeffrey, Phillip; Johnson, Christopher N; Macdonald, Gregor J; Nash, David J; Riley, Graham J; Smith, Alexander B; Stemp, Geoffrey; Thewlis, Kevin M; Vong, Antonio K.K; Wood, Martyn D
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 685 - 688
反应条件
hydrogen bromide
T=100°C; 2 h;
参考文献
Austin, Nigel E; Avenell, Kim Y; Boyfield, Izzy; Branch, Clive L; Hadley, Michael S; Jeffrey, Phillip; Johnson, Christopher N; Macdonald, Gregor J; Nash, David J; Riley, Graham J; Smith, Alexander B; Stemp, Geoffrey; Thewlis, Kevin M; Vong, Antonio K.K; Wood, Martyn D
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 685 - 688
