2,3-双(溴甲基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
in tetrahydrofuran; diethyl ether 2 h; Ambient temperature;
参考文献
Puyau, P. de Macedo; Perie, J. J.
Phosphorus, Sulfur and Silicon and the Related Elements, 1997 , vol. 129, p. 13 - 46
反应条件
1: 40 percent / Br2 / various solvent(s) / 5 h / 125 - 130 °C 2: 99 percent / diethyl ether; tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Puyau, P. de Macedo; Perie, J. J.
Phosphorus, Sulfur and Silicon and the Related Elements, 1997 , vol. 129, p. 13 - 46
反应条件
sodium hydroxide; tetrabutyl-ammonium chloride in water T=20°C; 18 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/14357 A2, 2004 ;
Location in patent: Page/Page column 45 ;
反应条件
1: 80 percent / 1 h / 180 °C / 10 Torr
2: H2, Ca(OH)2 / 10percent Pd/C / dioxane / 48 h / 2068.6 Torr
View Scheme
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 201 - 217
